EXPERT RESPONSE
If you have a workgroup (read: non-domain) environment, then make sure your share has write access enabled. If you have a domain, be sure that the individual accounts or the group account of the users trying to save changes to the file have write access to the account.
Additional information on Microsoft Excel and Microsoft Office:
Securing your Office
Microsoft Office vulnerabilities are not uncommon and most of your company's sensitive data is stored in an Office document. Contributor Tony Bradley recommends these best practices to make sure your Office is secure.
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